CELLULOSE SULFATE SALT HAVING ANTI-COAGULATING ACTION AND PROCESS FOR PREPARING SAME

摘要

CELLULOSE SULFATE SALT HAVING ANTI-COAGULATING ACTION AND PROCESS FOR PREPARING SAME A cellulose sulfate salt having a heparinic action is provided, which satisfies requirements of 0.8 ? <> ? 2.6, <> ? <> and <> ? <> wherein <>, <> and <> stand for probability of substitution of atoms in the OH groups bonded to the C2 , C3 and C6 positions of the glucopyranose rins unit by sulfuric acid radicals, respectively, and <> stands for the total substitution degree which is the sum of <>, <> and <>. The cellulose sulfate salt is prepared by reacting a cellulose having a crystal form I with an SO3/amine or SO3/amide complex in an amount of 2 to 4 mole equivalents per glucose unit of the cellulose at -10.degree.C to 40.degree.C to form a gelatinous product; adding water to the gelatinous product in an amount 0.1 to 5 times the amount of the starting cellulose used for the reaction; treating the mixture at a high temperature to relatively reduce the values of <> and <> among the values of <>, <> and <>; neutralizing, precipitating and drying the so obtained crude cellulose sulfate; dissolving the crude cellulose sulfate in water again; treating the solution with an adsorbent; and subjecting the treated cellulose sulfate to precipitation, drying, re-dissolution, dialysis, precipitation and then drying.