Sulfonamide compound

摘要

The present invention provides novel sulfonamide compounds having TRPM8 antagonistic activity which are useful as medicaments. Specifically, the present invention provides a sulfonamide compound of the formula (I):;
wherein Ring A is the following formula (i), (ii), or (ix):
;;R4 is optionally substituted alkyl,;X1 and X2 are each independently tetrazolyl, tetrazolinonyl, optionally substituted triazolyl, triazolinonyl, oxadiazolonyl, optionally substituted alkanoylaminomethyl, or optionally substituted alkylsulfonylaminomethyl, or;R4 and X2 combine with each other at their terminals together with the adjacent benzene to form indazolinonyl or benzoisoxazolonyl, and;the other symbols are the same as described in the specification,;or a pharmaceutically acceptable salt thereof.

主权项

1. A compound of the formula (I): wherein R1 is optionally substituted alkyl or optionally substituted cycloalkyl,
R2 is a hydrogen atom or optionally substituted cycloalkyl,R3 is optionally substituted alkyl or optionally substituted alkoxy,Z is CH or N,Ring A is the following formula (i), (ii), or (ix): R4 is optionally substituted alkyl,R6 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkoxy, optionally substituted alkylamino, optionally substituted dialkylamino, an optionally substituted monocyclic nitrogen-containing non-aromatic heterocyclic group, optionally substituted phenyl, or halogen,R7 is a hydrogen atom, optionally substituted alkyl, or halogen,X1 and X2 are each independently tetrazolyl, tetrazolinonyl, optionally substituted triazolyl, triazolinonyl, oxadiazolonyl, optionally substituted alkanoylaminomethyl, or optionally substituted alkylsulfonylaminomethyl, orR4 and X2 combine with each other at their terminals together with the adjacent benzene to form indazolinonyl or benzoisoxazolonyl, andY1 and Y2 are both CH, or one of Y1 and Y2 is CH, and the other is N, or a pharmaceutically acceptable salt thereof.