Process for the separation of mono- and di-carboxylic acid compounds

摘要

The present disclosure relates to processes for the separation of at least one di-carboxylic acid compound and/or at least one mono-carboxylic acid compound from a mixture. The separation processes involve contacting the mixture with an ion exchange medium to cause at least one of the mono- and/or di-carboxylic acid compounds to be retained by the medium, eluting at least one of the mono-carboxylic acid compound or the di-carboxylic acid compound using an eluent to form an eluate, wherein the eluate is enriched in at least one of the mono-carboxylic acid compound or di-carboxylic acid relative to the concentration of such eluted acid in the mixture having contacted the medium and wherein the eluent comprises an organic acid. The process has particular utility in the production of di-carboxylic acid compounds from glucose.

主权项

1. A process for the production of an adipic acid product, the process comprising the steps of oxidizing glucose to produce a mixture comprising at least one mono-carboxylic acid compound and at least one di-carboxylic acid compound, separating the at least one monocarboxylic acid compound in the mixture from the at least one di-carboxylic acid compound in the mixture, and converting at least a portion of the at least one di-carboxylic acid separated from the mixture to an adipic acid product, wherein separating the at least one monocarboxylic acid compound in the mixture from the at least one di-carboxylic acid compound in the mixture comprises the steps of:
(a) contacting the mixture with an anion exchange chromatography medium to cause the at least one mono-carboxylic acid compound and the at least one di-carboxylic acid compound to be retained by the anion exchange chromatography medium; (b) eluting the at least one mono-carboxylic acid compound from the anion exchange chromatography medium using a first eluent to form a first eluate; and (c) eluting the at least one di-carboxylic acid compound from the anion exchange chromatography medium using a second eluent to form a second eluate; wherein the first eluate is enriched in the at least one mono-carboxylic acid compound retained by the medium relative to the concentration of such acid in the first eluent and comprises at least about 50 wt % of the at least one mono-carboxylic acid compound retained by the anion exchange chromatography medium, the second eluate is enriched in the at least one di-carboxylic acid compound retained by the medium relative to the concentration of such acid in the second eluent, and wherein the first eluent consists essentially of water or comprises from about 1 to about 20 vol % of an organic acid in water and the second eluent comprises an organic acid, and the concentration of the organic acid in the second eluent is greater than the concentration of the organic acid in the first eluent.