Process for the preparation of hyperpolarized derivatives for use in MRI analysis

摘要

The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.

主权项

1. A process for preparing a hyperpolarized carboxylic organic acid for use in a method of magnetic resonance investigation, which comprises the steps of:
a) preparing a mixture of said carboxylic organic acid and an anhydride or ester precursor thereof that upon contact with an aqueous carrier provides at least said acid; b) subjecting the mixture of step a) to dynamic nuclear polarisation (DNP) methods to obtain a hyperpolarized mixture; and c) contacting the hyperpolarized mixture of step b) with an aqueous carrier to transform the precursor into the hyperpolarized carboxylic organic acid.