摘要 |
A 1-sulfo-2-oxoazetidine derivative of the formula <CHEM> wherein R<a> is -COQ<0> (Q<0> is an amino group which may optionally be protected or substituted), -COQ<5> (Q<5> is a hydroxyl group which may optionally be protected), -(CH2)na- R<4a> (n<a> is an integer of 1 to 3; R<4a> is a hydrogen atom or a carbamoylamino, N-sulfocarbamoylamino, carbamoyl, carbamoyloxy, N-sulfocarbamoyloxy, haloalkylcarbonylcarbamoyloxy, alkylsulfonyloxy, pyridinio, alkoxy, alkylsulfinyl, alkylsulfonyl, halogenoalkylcarbonyloxy, hydroxyl, alkoxycarbonyl, acyloxy, 1-alkoxyiminoalkyl, alkylcarbony or acylamino group) or a nitrogen-containing heterocyclic group; R<1> is an amino group which may optionally be acylated or protected; and X is a hydrogen atom or a methoxy group, or a salt or ester thereof, and methods of producing said compound (I<a>) which may be shown as follows <CHEM> wherein the symbols have the same meanings as respectively defined above, and intermediates for preparing the compound (I<a>) and methods of producing them. The compound (I<a>) has improved antimicrobial and beta -lactamase-inhibitory activities and is of value as drugs for human beings and domesticated animals.
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