| 摘要 |
<p>Disubstituted 1,4-piperazinyl derivatives are disclosed wherein one substituent is a bicyclic fused-ring furo-, pyrrolo-, cyclopentadieno-, or thieno-pyridine heterocyclic system and the second substituent is an alkylene chain attached to cyclic imide heterocycles, such as azospiro[4.5]decanediones, dialkylglutarimides, thiazolidinediones, succinimides, and morpholine-2,6-diones; or a fluorobenzylic carbinol moiety. These compounds have potent antipsychotic and serotonin antagonist activities. 4-[4-[4- (4-Furo[3,2-c]pyridinyl]-1-piperazinyl]-butyl]-3,5-morpholinedione is an example of a typical embodiment having selective antipsychotic activity.</p> |
