Antibodies Against TL1a and Uses Thereof

摘要

The disclosure provides TNF-like ligand 1a (TL1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to TL1a and inhibits interaction of TL1a and Death Receptor 3 (DR3) and which does not inhibit the interaction of TL1a and Decoy Receptor 3 (DcR3). The disclosure also provides uses of the TL1a-binding proteins.

主权项

1. A recombinant antibody that specifically binds to TL1a, comprising a variable heavy chain (VH) and a variable light chain (VL), wherein the VL comprises the following complementary determining regions (CDRs):
(i) a CDR1 comprising the sequence RASQSITNNLA comprising four or fewer amino acid substitutions; (ii) a CDR2 comprising the sequence DASTRAT comprising one or no amino acid substitution; and (iii) a CDR3 comprising the sequence QQYNNWPLT comprising three or fewer amino acid substitutions.