| 摘要 |
A controlled release tablet comprising I) a core, containing as essential components a) at least one water-soluble pharmaceutically active substance which is dispersed in a water-insoluble, non-digestible polymeric excipient, and b) a water-insoluble polymeric substance, which is swellable under the influence of water, and II) a coating consisting essentially of an elastic, water-insoluble and semipermeable diffusion film of a polymer, is presented, which shows a release pattern for the active substance(s) in a programmed rate of approximately zero order. |
