| 摘要 |
NEW MATERIAL:The compound of formula I (Y is piperidino, dimethylamino, 1-pyrrolidinyl, etc.; R is H or methyl; R1 is H, 1-3C alkyl or phenyl; A is 1-4C hydrocarbon residue; Z is 1-4C alkyl, thienyl, pyridyl, furyl, etc.; l is 1-5; m and n are 0 or 1; p is 0-2). EXAMPLE:N-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-(benzylthio)-aceta mide. USE:A remedy for peptic ulcer. It has activity to suppress secretion of gastric acid by its excellent antagonistic activity to histamine H2 receptor and is useful for the remedy of gastric and duedenal ulcer. PREPARATION:The compound of formula I can be produced by reacting the compound of formula II (X is halogen) with the compound of formula III in an inert solvent such as dichloromethane at 0 deg.C - refluxing temperature optionally in the presence of a condensation agent (e.g. alkali metal hydride). |
