INJECTABLE CROSS-LINKED COLLAGEN IMPLANT MATERIAL

摘要

INJECTABLE CROSS-LINKED COLLAGEN IMPLANT MATERIAL Cross-linked atelopeptide collagen that is a viscous fluid and substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers with glutaraldehyde at a concentration and under conditions that produce a viscous cross-linked collagen; quenching the cross-linking reaction with an amino acid; and separating the viscous cross-linked atelopeptide collagen from the reaction mixture. This collagen is dispersed in an isotonic aqueous medium for use in dermal augmentation and is injectable and forms implants that have excellent persistence.