Pyridazine derivatives and use thereof as medicaments for treating microRNA viral infection

摘要

Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.;

主权项

1. A method for treating a disease or disorder associated with an infection caused by a picornavirus in a subject in need thereof, wherein the disease or disorder is a common cold, which method comprises administrating a compound having Formula Ia or a pharmaceutically acceptable salt thereof to the subject, wherein
R1 is chlorine;n is 3 or 4; andR4 is a straight or branched C1-C6 alkyl, wherein the picornavirus is a rhinovirus.