Antihypertensive reduced pyridyl derivatives.

摘要

Dihydropyridine derivs. of formula (I) and their non-taxic pharmaceutically acceptable salts are new: the ring is a 1,2- or 1,4-dihydropyridine system; R1 = H lower alkyl, lower alkanoyl or lower alkoxycarbonyl; R2= lower alkyl or phenyl; R3= lower alkoxycarbonyl, (n,N-lower dialkylamino)-lower alkoxycarbonyl, (N-lower alkyl-N-phenyl-lower alkylamino)-lower alkoxycarbonyl, lower alkoxy-lower alkoxycarbonyl, N02 or CN; R4= pyridyl, N-lower alkoxycarbonyl, 1,2-dihydropyrodyl, N-lower alkanoyl-1,2-dihyropyridyl, N-phenoxycarbonyl-1,2-dihydropyridyl, N-lower alkoxycarbonyl- 1,6-dihydropyridyl, N-lower alkanoyl-1,6-dihydropyridyl, N-phenoxycarbonyl-1,6-dihydropyridyl, N-lower alkoxycarbonyl-1,4-dihydropyridyl, N-lower alkanoyl-1,4-dihydropyridyl, N-phenoxycarbonyl-1,4-dihydropyridyl, N-lower alkyl-1,2,3,6-tetrahydropyridyl, N-lower alkoxycarbonyl-1,2,3,6-tetrahydropyridyl, N-lower alkanoyl-1,2,3,6-tetrahyropyridyl, nitrophenyl or trifluoromethylphenyl; R5= lower alkoxycarbonyl, (N,N-lower dialkylamino)-lower alkoxycarbonyl, (N-lower alkyl-n-phenyl-lower alkylamino)-lower alkoxycarbonyl, lower alkoxy-lower alkoxycarbonyl, N02 or CN; R6 = lower alkyl or phenyl; lower= 1-6C.