| 发明名称 | Highly efficient influenza matrix (M1) proteins | ||
| 摘要 | This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs. | ||
| 申请公布号 | US9464276(B2) | 申请公布日期 | 2016.10.11 |
| 申请号 | US201514628513 | 申请日期 | 2015.02.23 |
| 申请人 | Novavax, Inc. | 发明人 | Smith Gale;Wu Yingyun;Massare Michael;Pushko Peter;Nathan Margaret;Kort Thomas;Robinson Robin |
| 分类号 | C12N7/00;C12N7/04;C12N9/24;A61K39/12;C07K14/005;A61K39/00 | 主分类号 | C12N7/00 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP ;Brown Fraser D. |
| 主权项 | 1. A method of increasing production of a VLP comprising expressing a mutated influenza M1 protein, an influenza HA protein, and an influenza NA protein in a host cell, wherein the mutated influenza M1 protein comprises an Arginine to Lysine mutation at the position corresponding to position 101 of SEQ ID NO: 49, wherein increased VLP release from the host cell is obtained with the M1 protein having the Lysine compared to VLP release obtained with an M1 protein having Arginine at the position corresponding to position 101 of SEQ ID NO: 49. | ||
| 地址 | Gaithersburg MD US | ||