| 摘要 |
Liposomal vesicles adapted for sustained delivery of therapeutic agents to the peritoneal cavity, and methods for their manufacture and use, are described. The liposomal vesicles, having a size of from about 1 micron to about 15 microns in diameter, comprise a lipid component further comprising a phospholipid component selected from the phosphatidylcholines having fatty acid side chains of from 12 to 24 carbons in length and incorporate a therapeutic agent which may be a non-steroidal anti-inflammatory drug, or an antimicrobial, antitumor, immunomodulatory or diagnostic agent. Administration may be achieved by intraperitoneal injection. These liposomal vesicles exhibit extended retention time in the peritoneal cavity, resulting in increased delivery of therapeutic agent and prolonged therapeutic effect for a given dose of therapeutic agent. This allows medical treatment using smaller doses and/or less frequent administration while still retaining a beneficial level of therapeutic activity. |
