| 发明名称 | Compositions and methods of producing methionine | ||
| 摘要 | Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed. | ||
| 申请公布号 | US9493801(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201514820453 | 申请日期 | 2015.08.06 |
| 申请人 | CJ CHEILJEDANG CORPORATION | 发明人 | Brazeau Brian;Chang Jin-Sook;Cho Kwang Myung;Cho Young Wook;Desouza Mervyn;Jessen Holly J.;Kim So-Young;Niu Wei;Sanchez-Riera Fernando A.;Shin Yong-Uk;Um Hyewon |
| 分类号 | C12N15/00;C12N15/74;C12N9/10;C12P13/12;C07H21/04;C12N15/70;C12N15/63 | 主分类号 | C12N15/00 |
| 代理机构 | Sterne, Kessler, Goldstein & Fox P.L.L.C. | 代理人 | Sterne, Kessler, Goldstein & Fox P.L.L.C. |
| 主权项 | 1. An isolated polynucleotide encoding an isolated polypeptide with homoserine O-suceinyltransferase activity, wherein the isolated polypeptide shows a reduced sensitivity to feedback inhibition by L-methionine as compared with a wild-type homoserine O-succinyltransferase polypeptide having the amino acid sequence of SEQ ID NO: 35, and comprises a mutation at one or more amino acid positions corresponding to amino acids 24, 29, 79, 114, 140, 163, 222, 275, 290, 291, 295, 297, 304 and 305 of SEQ ID NO: 35. | ||
| 地址 | Seoul KR | ||