<p>A process for isolating tPA which comprises contacting a cell culture medium with a solid support onto which the tPA becomes adsorbed, washing the support with water buffered to < pH 5 and then eluting the tPA with an aqueous solution of an alkali or alkaline earth metal salt or a chaotrope buffered to < pH 5.</p>
申请公布号
EP0294132(A2)
申请公布日期
1988.12.07
申请号
EP19880304907
申请日期
1988.05.31
申请人
SMITHKLINE BECKMAN CORPORATION
发明人
DEPHILLIPS, PETER ARLETTI;FRANKLIN, SAMUEL GREGG;JOHANSON, KYUNG OH;MCDEVITT, PATRICK JOSEPH;SITRIN, ROBERT DAVID;STRICKLER, JAMES EDWARD
