Process for producing 7-amino-6-demethyl-6-deoxytetracycline.

摘要

This invention provides a new process for producing 7-amino-6-demethyl-6-deoxytetracycline (Compound 3) which is an intermediate for the synthesis of minocycline. Compound 3 can be obtained by reduction of Compound 1 using a dithionite as reducing agent. This invention also provides a method to produce Compound 3 from Compound 2 in one pot. <CHEM> <CHEM> (wherein Ar denotes a substituted aryl group, and X stands for the residue of a mineral acid from which hydrogen atom has been eliminated).