Benzamide derivatives

摘要

Disclosed are benzamide derivatives having the formula;
wherein X is selected from the group consisting of H, halo, —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle, wherein the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle may be unsubstituted or substituted; Y is selected from the group consisting of H, —C1-C6 alkyl, and —C3-C7 cycloalkyl, the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle may be unsubstituted or substituted; Z is selected from the group consisting of —NHOH and phenylene diamine group (II) of structure
;
and wherein Q is selected from the group consisting of H, F and Cl. These benzamide derivatives are useful in slowing the expansion of cancer cells.

主权项

1. A compound of formula: wherein X is selected from the group consisting of H, halo, —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle, wherein the —C1-C6 alkyl, aryl, —C3-C7 cycloalkyl, and -3- to 10-membered heterocycle may be unsubstituted or substituted; wherein Y is selected from the group consisting of H, —C1-C6 alkyl, and —C3-C7 cycloalkyl, wherein the —C1-C6 alkyl, and, —C3-C7 cycloalkyl, may be unsubstituted or substituted; wherein Z is selected from the group consisting of —NHOH and phenylene diamine group (II) of structure and wherein Q is selected from the group consisting of H, F and C1; and all pharmaceutically acceptable salts and solvates thereof.