| 主权项 |
1. A method for treating inflammation or a disease selected from asthma, allergic rhinitis, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), atopic dermatitis and acne, in a patient in need thereof said method comprising administering an effective amount of a compound of Formula II wherein X1, X2, X3 and X4 are independently selected from the group consisting of H, halogen, alkyl group, aralkyl group and OR5 wherein R5 is selected from the group consisting of H, acyl, alkyl, aralkyl, alkenyl, alkoxy, aryl, haloalkyl, cycloalkyl, haloalkoxy, heterocycloalkyl, cycloalkenyl and heterocycloalkenyl, any of which may be optionally substituted; and i) R1 is (CO)alkyl-COOH, said alkyl is straight or branched and optionally substituted with C3-7 cycloalkyl; R2 is alkyl, said alkyl is straight or branched and optionally substituted with OH, SH, COOR6, NR6R7, a C6-16 aryl, a C6-16 heterocycle, a C3-7 cycloalkyl, or a heterocyclic ring, wherein R6 and R7 are a C6-16 aryl, C6-16 heterocycle, C3-7 cycloalkyl, a heterocyclic ring or a hydrophobic group; R3 is alkyl; or ii) R1 is H R2 is alkyl, said alkyl is straight or branched and optionally substituted with OH, SH, COOR6, NR6R7, C6-16 aryl, C6-16 heterocycle, C3-7 cycloalkyl, or a heterocyclic ring, wherein R6 and R7are a C6-16 aryl, C6-16 heterocycle, C3-7 cycloalkyl, or a heterocyclic R3 is (CO)alkyl-COOH, said alkyl is straight or branched and optionally substituted with C3-7 cycloalkyl; or a pharmaceutically acceptable salt thereof. |
