发明名称 |
Alkylated cyclodextrin compositions and processes for preparing and using the same |
摘要 |
The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride. |
申请公布号 |
US9493582(B2) |
申请公布日期 |
2016.11.15 |
申请号 |
US201314381568 |
申请日期 |
2013.02.27 |
申请人 |
Cydex Pharmaceuticals, Inc. |
发明人 |
Antle Vincent D.;Lopes Alvaro;Monteiro Daniel |
分类号 |
C08B37/16;A61K47/40;C08L5/16;A61K38/07 |
主分类号 |
C08B37/16 |
代理机构 |
Knobbe Martens Olson & Bear LLP |
代理人 |
Knobbe Martens Olson & Bear LLP |
主权项 |
1. A process for preparing an alkylated cyclodextrin composition comprising an alkylated cyclodextrin, the process comprising:
(a) mixing a cyclodextrin with an alkylating agent to form a reaction milieu comprising an alkylated cyclodextrin, one or more unwanted components, and one or more drug-degrading impurities; (b) conducting one or more separations to remove the one or more unwanted components from the reaction milieu to form a partially purified solution comprising the alkylated cyclodextrin and the one or more drug-degrading impurities, wherein the one or more separations are ultrafiltration, diafiltration, centrifugation, extraction, solvent precipitation, or dialysis; and (c) treating the partially purified solution with a phosphate-free activated carbon having a residual conductivity of 10 μS or less and producing the alkylated cyclodextrin. |
地址 |
San Diego CA US |