Peptides associated with HLA-DR MHC class II molecules involved in autoimmune diseases

摘要

Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an increased affinity for HLA-DR molecules and associated with Rheumatoid arthritis. These novel peptides provide the basis for new methods of diagnosis and treatment of Rheumatoid arthritis.

主权项

1. A peptide comprising the sequence: Cit-Cit-Y-Cit-G-Cit-Cit-S-Cit-Cit-S-Cit-Cit (SEQ ID NO. 39), wherein the peptide is circularized.