| 发明名称 | AKT ligands and polynucleotides encoding AKT ligands | ||
| 摘要 | The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate AKT activity. The ligands, homopolyligands, and heteropolyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands, homopolyligands, and heteropolyligands. | ||
| 申请公布号 | US9493525(B2) | 申请公布日期 | 2016.11.15 |
| 申请号 | US201414335550 | 申请日期 | 2014.07.18 |
| 申请人 | Intrexon Corporation | 发明人 | Reed Thomas D. |
| 分类号 | C12Q1/48;C12N15/00;C12N1/20;C12P21/06;C07H21/04;C07K14/47;C07K14/00;C12N15/62;C07K14/435 | 主分类号 | C12Q1/48 |
| 代理机构 | Sterne, Kessler, Goldstein & Fox P.L.L.C. | 代理人 | Sterne, Kessler, Goldstein & Fox P.L.L.C. |
| 主权项 | 1. An isolated polynucleotide comprising a polynucleotide sequence encoding a polypeptide heteropolyligand wherein said polypeptide heteropolyligand comprises (a) a sequence at least 90% identical to SEQ ID NO:90 and SEQ ID NO:174; (b) a sequence at least 90% identical to SEQ ID NO:102 and SEQ ID NO:174; (c) a sequence at least 90% identical to SEQ ID NO:194 and SEQ ID NO:174; or (d) a sequence at least 90% identical to SEQ ID NO:195 and SEQ ID NO:174; wherein Xaa is any amino acid, and wherein the polypeptide heteropolyligand inhibits the kinase activity of mammalian protein kinase B (AKT). | ||
| 地址 | Blacksburg VA US | ||