发明名称 VERFAHREN ZUR HERSTELLUNG WAESSRIGER MISCHMICELLOESUNGEN
摘要 A process for producing aqueous mixed micelle solutions containing mixed micelles formed from lipoids and salts of bile acids, in which, if desired, active substances hardly soluble or insoluble in water are solubilized, is characterized in that the free bile acids are suspended in an aqueous solution possibly containing isotonizing additives and/or water-soluble active substances at a temperature of 40 DEG C to 100 DEG C, the lipoids are dispersed in this suspension at a temperature of 40 DEG C to 100 DEG C and the dispersion obtained is neutralized with bases at a temperature of 0 DEG C to 100 DEG C, provided that, if necessary, the active substances which are hardly soluble or insoluble in water are dispersed together with the lipoids or solubilized in the mixed micelle solution which does not contain these active substances.
申请公布号 DE3903753(A1) 申请公布日期 1990.08.23
申请号 DE19893903753 申请日期 1989.02.06
申请人 SCHERING AG, 1000 BERLIN UND 4709 BERGKAMEN, DE 发明人 MICHEL, HEINRICH, DR.;GOERITZ, DETLEF;ROESSLING, GEORG, DR.;TACK, JOHANNES-WILHELM, DR., 1000 BERLIN, DE
分类号 A61K;A61K9/107;A61K47/28;B01J13/00 主分类号 A61K
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