| 摘要 |
Disclosed are paucilamellar lipid vesicles reinforced with polyacrylamide, and methods of producing the same. The vesicles include about 2-10 lipid bilayers (20) in the form of substantially spherical shells separated by a plurality of aqueous layers (30). Each of the bilayers have a layer of polyacrylamide (32) lining its innermost side. The bilayers and the aqueous layers surround a large, substantially amorphous central cavity (10) containing a water-immiscible oily phase or a polyacrylamide core. The method of the invention includes forming a lipophilic phase containing a surfactant and a lipid-soluble material to be encapsulated or to be incorporated into the lipid structure of the vesicle; forming an aqueous phase containing polyacrylamide; shear mixing the lipophilic phase and the aqueous phase, thereby forming a plurality of paucilamellar lipid vesicles containing acrylamide in their aqueous regions; separating the vesicles form any unincorporated vesicle constituents; and polymerizing the acrylamide in the aqueous layers of the vesicles. A method of encapsulating a water-soluble material is also disclosed. |
