发明名称 |
PEPTIDES FROM GTPASE-ACTIVATING PROTEIN (GAP) AND DIAGNOSTIC AND THERAPEUTIC USE THEREOF |
摘要 |
2065017 9102749 PCTABS00003 Peptides, that inhibit GAP stimulated ras p21 hydrolysis of GTP; peptides that mediate dissociation of GDP from ras p21-GTP complex; and antibodies to the peptides are described. These peptides are useful as cancer diagnostics and therapeutics, particularly to detect cancer cells with an over expression of normal or oncogenic ras p21 protein and to treat cancer caused by ras oncogene. Methods for assaying products of oncogenes using the described peptides and antibodies are also disclosed. Method for treating cancer caused by ras oncogenes is also disclosed. Prefered peptides are (Thr)-Met-Arg-Thr-Arg-Val-Val-Ser-Gly-Phe-Val-Phe-Lev-Arg-Lev-Ile-Cgs.
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申请公布号 |
CA2065017(A1) |
申请公布日期 |
1991.02.22 |
申请号 |
CA19902065017 |
申请日期 |
1990.08.20 |
申请人 |
CETUS CORPORATION |
发明人 |
MCCORMICK, FRANCIS P.;WONG, GAIL L.;POLAKIS, PAUL G.;RUBINFELD, BONNIE |
分类号 |
A61K38/00;A61K39/395;A61P35/00;C07K7/08;C07K14/47;C07K16/00;C07K16/18;G01N33/53;G01N33/566;G01N33/573;(IPC1-7):C07K7/08;A61K38/10;G01N33/574 |
主分类号 |
A61K38/00 |
代理机构 |
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主权项 |
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地址 |
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