发明名称 |
Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer |
摘要 |
Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino} acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2a) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino} acetic acid and/or a prodrug thereof which can be used to treat cancer. |
申请公布号 |
AU2012268400(C1) |
申请公布日期 |
2016.12.22 |
申请号 |
AU20120268400 |
申请日期 |
2012.06.05 |
申请人 |
Akebia Therapeutics Inc. |
发明人 |
Shalwitz, Robert;Gardner, Joseph H.;Janusz, John M. |
分类号 |
C07D213/81;A61K31/195 |
主分类号 |
C07D213/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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