NEW DIPHOSPHONIC ACID DERIVATIVES CONTAINING AMIDINE GROUPS, PROCESS FOR PREPARING THEM AND DRUGS CONTAINING THESE COMPOUNDS

摘要

Compounds of the formula I I in which R can be hydrogen or C1-C4-alkyl, R1 hydrogen, C1-C6-alkyl, aryl, aryl-C1-C4-alkyl, amino-C1-C6-alkyl, C1-C6-alkylamino-C1-C4-alkyl, C1-C6-dialkylamino-C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C3-C7-alkenyl, R2 R1 or C2-C7-alkenyl, C1-C6-alkylmercapto, C1-C6-alkoxy, phenoxy-C1-C4-alkyl,amino, C1-C4-alkylamino, di-C1-C4-alkylamino, morpholino, thiomorpholino, pyrrolidino, piperidino, hexamethyleneimino, pyrasolino, imidazolino, n 0, 1 or 2 and R1 and R2, together with the carbon and the nitrogen atom to which they are attached, can form a heterocyclic five-, six- or seven-membered ring with 1-4 heteroatoms, whereby the heteroatoms can be the same or different and signify oxygen, nitrogen or sulphur and the annelated ring can possibly be substituted by one or more C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylmercapto groups, hydroxyl, amino, nitro, halogen or halomethyl, as well as their pharmacologically acceptable salts, processes for their preparation, as well as medicaments which contain these compounds for the treatment of calcium metabolism disturbances.