PROCESS FOR THE PRODUCTION OF 3-(1-AMINO-1,3-DICARBOXY-3-HYDROXY-BUT-4-YL)INDOLE

摘要

The invention provides a process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole and certain salts and internal condensation products thereof. An unsaturated indolyl ester is reacted with ethylchloro(hydroxyimino)acetate in the presence of triethylamine in an organic solvent to cause a 1,3-polar addition reaction to form a di-ester. The di-ester is saponified to form a diacid which di-acid is then reduced to form either the product indole or a salt thereof.