IONENAUSTAUSCHERHARZE BELADEN MIT CHINOLONCARBONSAEUREDERIVATEN, IHRE HERSTELLUNG UND VERWENDUNG.

摘要

Ion-exchange resins loaded with quinoline carboxylic acid derivs. of formula (I) are new, where R1 = 1-3C alkyl, cyclopropyl, vinyl, CH2CH2OH, CH2CH2F, OMe, NH2, NHMe, NMe2, NHEt, phenyl, 4-fluorophenyl or 2,4-difluorophenyl; R2 = H, 1-4C alkyl or 5-methyl-2-oxo -1,3-dioxol-4-ylmethyl; R3 = Me or a cyclic amino gp., e.g. 3-R1-4-R8-pyrrolidino, piperidino, 4-hydroxypiperidino, 3-R5-4-R4-5-R6-1 -piperazinyl, morpholino, thiomorpholino, 5-R4-2,5- diazabicyclo (2,2,1)hept-2-yl, 5-R4-2,5- diazabicyclo (2,2,2)oct-2-yl, 1,4-diazabicyclo (2,2,2)oct-4-yl, 1H-imidazol-1-yl or 1H-pyrrol-1-yl; R4 = H, 1-4C alkyl, CH2CH2OH, alkyl, propargyl, 2-oxopropyl, 3-oxobutyl, phenacyl, CHO, SCFCl2, SO2CFCl2, SCOOMe, benzyl, 4-aminobenzyl or 5-methyl-2-oxo-1,3-dioxal-4-ylmethyl; R5 = H or Me; R6 = H, 1-4C alkyl, phenyl or benzyloxymethyl; R7 = H, NH2, NHMe, NHEt, CH2NH2, CH2NHMe, CH2NHEt, CH2NMe2, OH or CH2OH; R8 = H, Me, Et or Cl; X = F, Cl or NO2; A = N or CR9; R9 =) H, halogen, Me or NO2; or R9 + R1 = OCH2CHMe, SCH2CHMe or CH2CH2CHMe. (I) are described in DE3033157.