PROCESS FOR PREPARING PIPERAZINYL QUINOLONE DERIVATIVES

摘要

Prepn. of piperazinyl guinoline derivs. of formula (I) comprises reacting dihaloguinolines of formula (II) with trialkylsilyl piperazines of formula (III) in the presence of a tetraalkyl ammonium halide of formula (IV) in a polar solvent at 60-80 deg.C for 2-3 hrs. In the formulas, R1=C1-6 alkyl, chclopropyl or -OCH2CHMe-, with the O atom linked to the 8 position in the quioline; R2=H, Me or Et, R3-R5=C1-6 lower alkyl gps., selected from Me, Et or t-Bu; R6=Me, Et or Bu. (I) are broad spectrum fungicides.