Pharmaceutically active aryl-substituted amine derivatives.

摘要

Compounds of formula (IVa) <CHEM> wherein: R<1><9> is -CH2CH2-, -CH2O-, -OCH2-, -NHCH2-, or -CH2NH-; Y is hydrogen or halogen attached at the 1, 2, 3 or 4 position; Y' is hydrogen or halogen attached at the 7, 8, 9 or 10 position; n is 0 to 3; each of p and q is 1 to 4; and R<2><0> and R<2><1> independently are hydrogen, or C1-4 alkyl, or together with the nitrogen atom form a nitrogen-containing heterocyclic ring having four to six ring members, with the provisos that a) when R<1><9> is -CH2CH2-, -CH2O- or -OCH2-, p and q are each 1 and one of Y and Y' is halogen, the other is not hydrogen; and b) when R<1><9> is -CH2CH2- or -CH2O-, p and q are both 1 and each of Y and Y' is hydrogen or halogen, then n is not 2; or pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical formulations containing them.