发明名称 |
IMPROVED HIGH CONCENTRATION ANTI-TNF.ALPHA. ANTIBODY LIQUID FORMULATIONS |
摘要 |
The invention provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, which reduces pain associated with injection in a subject by at least about 50% when compared to injecting an otherwise identical formulation comprising at least one salt and/or at least one buffer. The invention also provides a liquid aqueous pharmaceutical formulation comprising a human anti-TNFa antibody, or antigen-binding portion thereof, having increased bioavailability upon subcutaneous administration into a subject. The formulation may comprise a therapeutic protein, such as a human anti-TNF-alpha antibody, or an antigen- binding portion thereof, or a biosimilar thereof. |
申请公布号 |
CA2815689(C) |
申请公布日期 |
2016.11.22 |
申请号 |
CA20112815689 |
申请日期 |
2011.11.11 |
申请人 |
ABBVIE BIOTECHNOLOGY LTD. |
发明人 |
NEU, MICHAEL;TSCHOEPE, MARKUS;WEBER, CARSTEN;REDDEN, LAURA;FRAUNHOFER, WOLFGANG;GASTENS, MARTIN;FEICK, ALEXANDER;PAULSON, SUSAN K.;ZHU, TONG |
分类号 |
A61K9/08;A61K39/395;A61K47/10 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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