| 摘要 |
<p>NEW MATERIAL:A peptide wherein the same or different T cell-recognizing sites of an acetyl choline acceptor alpha-subunit are conjugated to both the terminals of a B cell-recognizing site. USE:A drug treating and diagnosing myasthenia gravis. PREPARATION:The peptide wherein the same or different T cell-recognizing sites of an acetyl choline acceptor alpha subunit are conjugated to both the terminals of a B cell-recognizing site is synthesized e.g. by a solid phase synthetic method. An amino acid sequence whose alpha-amino groups, etc., are protected is bound in order to a solid carrier from the C-terminal side of the peptide in accordance to the amino acid sequence of the peptide in the presence of a condensing agent, and the alpha-amino-protecting group, is removed. The processes are repeated to synthesize a protected peptide chain on the solid carrier, and the product is subjected to a protecting group-removing reaction and to the separation of the peptide from the solid carrier by the use of an HF reaction device, followed by purifying the peptide by a high performance liquid chromatography to provide the novel peptide.</p> |
