| 摘要 |
This invention is directed to a triphenylalkene derivative represented by the following general formula (1) or a pharmaceutically acceptable acid addition salt thereof, and it provides a pharmaceutical composition, which possesses a tumor inhibition function and also has osteoporosis curing activity: <IMG> (2) <IMG> (1) <IMG> (3) <IMG> (4) wherein R1 is selected from the formulae (2), (3) and (4), R6 and R7 is a hydrogen atom, an alkyl group or a cycloalkyl group, or forms a heterocyclic group together with the adjoining nitrogen atom (but R6 and R7 are not hydrogen atoms at the same time); R8 represents a hydrogen atom or an alkylcarbonyl group; R2 represents an alkyl group or a cycloalkyl group; R3 represents a 3,4-methylenedioxylphenyl group: R4 represents a hydrogen atom, a hydroxyl group, R9C(O)O-, R10OCH2O-, OPO(OH)2 or CH=NOR11; R9 represents an alkyl group and R10 represents an alkyl group or an alkylcarbonyl group; R5 represents a hydrogen atom or CH=NOR11; and R11 represents a hydrogen atom, an alkyl group, a substituted alkyl group.
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