摘要 |
HOE 86/F 253 of the disclosure: Analogs of gonadoliberin with improved solubility, methods for their preparation, agents containing them and their use The invention relates to peptides of the formula in which X is absent or is hydrogen or acyl; A is Pgl, dehydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; .beta. is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg or His; E is D-Ser(R1), .beta.Asn, .beta.-Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NHalkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use. |