| 摘要 |
Simple amides and derivatives thereof useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. The amides and derivatives are represented by the formula: (wherein HET is or a group of the formula where X is hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy, fluoro, chloro, bromo or cyano; Y is hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy, fluoro or chloro; R4 is hydrogen or (C1-C3)alkyl; n is an integer of 0 to 2; R1 is (C6-C8)cycloalkyl or i-propyl; R2 is (C3-C5)alkyl, phenyl, methylvinyl, dimethylvinyl, halovinyl, hydroxy(C1-C3)alkyl or amino(C1-C4)alkyl; and R3 is (C1-C6)alkyl or morpholinoethyl, and their pharmaceutically acceptable salts. |
