IDENTIFYING MEMBRANOLYTIC COMPOUNDS AND PRECURSORS THEREOF

摘要

The present invention includes testing of substances identified by a screening process as likely to be taken up by (and then deactivate) certain cells containing dipeptidyl peptidase I. The process comprises the steps of screening for substances inhibitory for the uptake or binding by PBL, NK or CTL cells of a known inhibitor or of a substance which itself inhibits said known inhibitor; comparing lysis induced in human erythrocytes by screened compounds and known inhibitors; distinguishing among the identified inhibitory substances which are taken up by PBL, NK or CTL cells those likely to cause lysis; and lastly applying to cells effective amounts of distinguished inhibitory substances which are lethal to cells taking them up or which are converted by dipeptidyl peptidase I to membranolytes.