| 发明名称 |
FARNESYL PYROPHOSPHATE ANALOGS |
| 摘要 |
105/MRD68 109/MRD71 18500 TITLE OF THE INVENTION FARNESYL PYROPHOSPHATE ANALOGS The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnecyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesylprotein transferase and the farnesylation of the oncogene protein Ras.
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| 申请公布号 |
CA2079080(A1) |
申请公布日期 |
1993.03.28 |
| 申请号 |
CA19922079080 |
申请日期 |
1992.09.24 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
ANTHONY, NEVILLE J.;LEE, TA-JYH;SMITH, ROBERT L.;STOKKER, GERALD E. |
| 分类号 |
C07F9/24;C07C43/30;C07C45/29;C07C47/21;C07C59/42;C07C233/04;C07C233/05;C07F9/38;C07F9/40;(IPC1-7):C07F9/38;A61K31/19;A61K31/66;C07C235/74 |
主分类号 |
C07F9/24 |
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