VANADIUM COMPLEXES,PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Compounds of formula (I): (I) in which: R1 or R4, which are identical or different, represent hydrogen or alkyl, R2 represents hydrogenm or alkyl, hydroxymethyl, -CH2OPO(OH)2 or -CH2OPO(ONa)2, R3 represents hydrogen, alkyl or hydroxyl or any one of the following groups: in which: T represents oxygen or sulfur, n represents an integer between 1 and 4, R5 represents hydrogen or alkyl, X represents nitrogen, CH or CR'3 (in which R'3 has the same meaning as R3 except in the case where R3 represents hydroxyl), A represents alkylene of formula -(CH2)p-in which p represents an integer between 2 and 4, optionally substituted by one or more linear or branched (C1-C4) alkyl, or any one of the following radicals: Y and Z together form oxygen or simultaneously represent two hydroxyl and in this case, the compound of formula (I) is positively charged, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base.