Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols

摘要

A water-soluble substantially non-immunogenic conjugate of superoxide dismutase is prepared by coupling to a polyalkylene glycol which is polyethylene glycol or polyethylene-polypropylene glycol copolymer, wherein said glycol has an average molecular weight of 40,000-1,000,000 and is terminally unsubstituted or substituted by C14-alkyl or C14 alkoxy groups. The conjugates have long action as anti-inflammatory agents.