MULTIFUNCTIONAL LIGANDS FOR POTENTIAL USE IN THE DESIGN OF THERAPEUTIC OR DIAGNOSTIC RADIOPHARMACEUTICAL IMAGING AGENTS

摘要

A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, or a second phosphinimine moiety. These phosphinimine ligands are complexed to early transition metal radionuclides (e.g. <99m>Tc or <186>Re/<188>Re) or late transition metals (e.g., <105>Rh or <109>Pd). The complexes with these metals <186>Re/<188>Re, <99m>Tc and <109>Pd exhibit a high in vitro and high in vivo stability. The complexes are formed in high yields and can be neutral or charged. These ligands can also be used to form stable compounds with paramagnetic transition metals (e.g. Fe and Mn) for potential use as MRI contrast agents. Applications for the use of ligands and making the ligands are also disclosed.