MICROBIOLOGICAL PROCESS FOR THE PRODUCTION OF MALONYL-7-AMINOCEPHALOSPORANIC ACID DERIVATIVES

摘要

Microorganisms are selected for the ability to utilize lactone of the formula: I and soluble salts thereof, as the sole carbon, nitrogen and energy source via malonyl-lactone of the formula: II and soluble salts thereof, without catabolism of the latter. Further, a microbiological process is disclosed for the production of a malonyl-7-aminocephalosporanic acid derivative of the general formula: III or a soluble salt thereof, wherein R represents a hydrogen atom, a hydroxyl group or an acetoxy group, from a cephalosporin C derivative of the general formula: IV or a soluble salt thereof, wherein R has the above-stated meaning. Also a new process is described for the conversion of a malonyl-7-amino-cephalosporanic acid derivative to a 7-aminocephalosporanic acid derivative of the general formula: V or a soluble salt thereof, wherein R has the above-stated meaning.