| 摘要 |
Piperidine derivatives of formula <IMAGE> (I) wherein A is a radical of formula -CH2-CH2-(a-1), -CH2-CH2-CH2-(a-2), or -CH2-CH2-CH2-CH2-(a-3), wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C1-6alkyl radical; R1 is hydrogen or halo; R2 is hydrogen, amino, mono or di(C1-6alkyl)amino or C1-6alkylcarbonylamino; R3 is hydrogen or C1-6alkyl; L is C3-6cycloalkyl, C5-6cycloalkanone, C3-6alkenyl optionally substituted with aryl, or L is a radical of formula -Alk-R4(b-1), -Alk-X-R5(b-2), -Alk-Y-C(=O)-R7(b-3), or -Alk-Y-C(=O)-NR9R10(b-4), the N-oxide forms, addition salts and stereochemically isomeric forms thereof, said compounds having gastrointestinal motility stimulating properties. Pharmaceutical compositions containing these compounds as active ingredient, and a method of preparing said compounds and pharmaceutical compositions.
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