| 发明名称 |
Humanized monoclonal antibodies. |
| 摘要 |
<p>A method of preparing humanized monoclonal antibodies is described which utilizes comparative model burding methodology. A humanized anti-CD18 antibody, 60.3, has been formulated and demonstrated to have analogous binding characteristics to the original murine monoclonal antibody, while displaying essentialy complete human Ig heavy and light chains.</p> |
| 申请公布号 |
EP0578515(A2) |
申请公布日期 |
1994.01.12 |
| 申请号 |
EP19930401328 |
申请日期 |
1993.05.24 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
HARRIS, LINDA J.;BAJORATH, JURGEN;KU-CHUAN, HSIAO |
| 分类号 |
C07K16/46;C12N15/13;C12P21/08;(IPC1-7):C12N15/13 |
主分类号 |
C07K16/46 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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