Pyrrolidine derivatives and pharmaceutical compositions thereof

摘要

Pyrrolidine muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of the formula:- and their pharmaceutically acceptable salts, wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; R is -CN or -CONH2; and R<1> is a group of the formula:- where X and X<1> are each independently O or CH2; m is 1, 2 or 3; and "Het" is pyridyl, pyrazinyl or thienyl. u