发明名称 |
Microbial transformation product having immunosuppressive activity |
摘要 |
Microbial transformation of a macrolide immunosuppressant by the microorganism Streptomyces sp., (Merck Culture Collection MA 6960) ATCC No. 55387 yields a compound of the structural formula (I): <IMAGE> I <IMAGE> This compound is an immunosuppressant useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
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申请公布号 |
US5352783(A) |
申请公布日期 |
1994.10.04 |
申请号 |
US19930074258 |
申请日期 |
1993.06.09 |
申请人 |
MERCK & CO., INC. |
发明人 |
SHAFIEE, ALI;ARISON, BYRON H.;CHEN, SHIEH-SHUNG T.;MILLER, RANDALL R.;STEARNS, RALPH A. |
分类号 |
C07D498/18;C12P17/18;C12P19/44;(IPC1-7):C07D491/16;A61K31/345;C12P17/14 |
主分类号 |
C07D498/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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