发明名称 |
Compositions and methods for inhibiting hepatocyte invasion by malarial sporozoites |
摘要 |
There is provided peptide and mimetic inhibitors for the binding of a circumsporozoite polypeptide to receptors of hepatocytes from malaria-susceptible mammals. Aslo contemplated is a method of inhibiting the binding of a malaria sporozoites to hepatocytes susceptible to sporozoite invasion. A peptide of Region II+ of the circumsporozoite protein is also provided, as is a method of targeting the delivery of substances to hepatocytes. |
申请公布号 |
AU7724894(A) |
申请公布日期 |
1995.03.27 |
申请号 |
AU19940077248 |
申请日期 |
1994.09.09 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
CARLA CERAMI;UTE FREVERT;PHETORI SINNIS;VICTOR NUSSENZWEIG |
分类号 |
A61K38/00;C07K14/445;C07K14/705;C12N15/87 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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