发明名称 |
Fluorogenic and chromogenic three-dimensional ionophores as selective reagents for detecting ions in biological fluids |
摘要 |
Novel fluorogenic and chromogenic three-dimensional ionophores are provided which selectively bond ions such as potassium, sodium, and lithium, even in neutral aqueous or alcohol media. The novel ionophores comprise an "ion-recognizing system" fused to a "signal-moiety" through one or more heteroatoms having a non-bonded electron pair. The signal-moieties are selected from the group consisting of fused ring heterocyclics, fused aromatics, and subsituted aromatics having at least one nitro or azo moiety. The ion-recognizing system is a three-dimensional cryptand. The ionophores are ideal for the selective and direct termination of ions in biological or environmental samples and the like.
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申请公布号 |
US5439828(A) |
申请公布日期 |
1995.08.08 |
申请号 |
US19910621510 |
申请日期 |
1991.06.26 |
申请人 |
ALLIEDSIGNAL INC. |
发明人 |
MASILAMANI, DIVAKARAN;LUCAS, MARIANN E.;HAMMOND, GEORGE S. |
分类号 |
G01N31/00;A61K49/00;C07D498/08;C07D498/18;C07D498/22;G01N33/84;G01N33/86;(IPC1-7):G01N21/64 |
主分类号 |
G01N31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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