| 摘要 |
The present invention relates to a pharmaceutical composition for preventing and/or treating dyslipidemia, comprising: (a) a compound represented by the following general formula (1), wherein Rand R, which may be identical or different, each represents a hydrogen atom, a methyl group, or an ethyl group; R, R, Rand R, which may be identical or different, each represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a Calkyl group, a trifluoromethyl group, a Calkoxy group, a Calkylcarbonyloxy group, a di-Calkylamino group, a Calkylsulfonyloxy group, a Calkylsulfonyl group, a Calkylsulfinyl group, or a Calkylthio group, or Rand R, or Rand Rare joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N-R(wherein Rrepresents a hydrogen atom, a Calkyl group, a Calkylsulfonyl group, or a Calkyloxycarbonyl group); Y represents an oxygen atom, a S(O)group (wherein l represents 0, 1 or 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH, or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, or a solvate of the compound, or a solvate of the salt of the compound; and (b) a cholesterol absorption inhibitor. The invention solves the problem of the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia and low HDL blood disease in mammals including humans. |
