SYNTHETIC PEPTIDE DERIVATIVES AND THE SALTS THEREOF

摘要

The present invention provides synthetic peptide derivatives represented by the formula P1-R1-P2 wherein P1 is a peptide having an amino acid sequence in the SEQ ID NO.:1 of theSequence Listing, or analogues thereof; P2 is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R1 denotes a linker with a property that does not interfere with the activity of each peptide P1 and P2 to bind the N-terminal end of the peptides P1 and P2. The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof.